| Definitive Brewing Company | 35 Industrial Way | Portland | Maine | 04103-1071 | United States | micro | |
| Deft Brewing | 5328 Banks St | San Diego | California | 92110-4008 | United States | micro | |
| Del Cielo Brewing Co. | 701 Escobar St Ste A | Martinez | California | 94553-1150 | United States | micro | |
| Delafield Brewhaus | 3832 Hillside Dr | Delafield | Wisconsin | 53018-2174 | United States | brewpub | |
| Delicious Science Brewing | 11626 Sterling Ave Ste G | Riverside | California | 92503-4991 | United States | closed | |
| Delta Sunshine Brewing Company | | Memphis | Tennessee | 38120-8859 | United States | planning | |
| Deluxe Brewing Co | PO Box 3358 | Albany | Oregon | 97321-0713 | United States | micro | |
| Demented Brewing Co. | 600 Lincoln Blvd | Middlesex | New Jersey | 08846-2443 | United States | micro | |
| Democracy Brewing | 35 Temple Pl | Boston | Massachusetts | 02111 | United States | brewpub | |
| Dempsey's Brew Pub and Restaurant - Baltimore | 333 W Camden St | Baltimore | Maryland | 21201 | United States | brewpub | |
| Dempsey's Restaurant And Brewery | 50 E Washington St | Petaluma | California | 94952-3115 | United States | brewpub | |
| Dempseys Brewery, Pub | 127 N Broadway | Watertown | South Dakota | 57201-3525 | United States | brewpub | |
| Denali Brewing Company | 37083 Talkeetna Spur Rd | Talkeetna | Alaska | 99676 | United States | micro | |
| Denizens Brewing Company | 1115 E West Hwy | Silver Spring | Maryland | 20910-4852 | United States | brewpub | |
| DeNovo Beverage of Monmouth | 105 S A St | Monmouth | Illinois | 61462-1706 | United States | micro | |
| Dented Face Brewing Company | | Delta | Colorado | 81416 | United States | planning | |
| Denton County Brewing Company | 200 E McKinney St | Denton | Texas | 76201-4230 | United States | micro | |
| Denver Beer Co | 1695 Platte St | Denver | Colorado | 80202-1123 | United States | micro | |
| Denver Beer Co - Littleton | 2409 Main St | Littleton | Colorado | 80120 | United States | micro | |
| Denver Beer Co Canworks | 4455 Jason St | Denver | Colorado | 80211-2412 | United States | micro | |
| Denver Beer Co Olde Town Arvada | 5768 Olde Wadsworth Blvd | Arvada | Colorado | 80002-2549 | United States | micro | |
| Departed Soles Brewing | 150 Bay Street, Commercial Side | Jersey City | New Jersey | 07302-2900 | United States | micro | |
| Department Coffee | 1940 N 30th Rd | Hollywood | Florida | 33021-4401 | United States | contract | |
| Depot Deli and Lounge | 101 N Railroad St | Shenandoah | Iowa | 51601-1158 | United States | brewpub | |
| Depot Saloon | 9 S Race St | Greenville | Pennsylvania | 16125-2213 | United States | brewpub | |
| Depot Street Brewing Co | 904 Depot St | Jonesborough | Tennessee | 37659-5662 | United States | micro | |
| Der Blokken Brewery | 1100 Perry Ave Unit C | Bremerton | Washington | 98310-4945 | United States | closed | |
| Derive Brewing company | 2808 N. High St. | Columbus | Ohio | 43206 | United States | micro | |
| Descendants Brewing Company | 61 Bridge St | Milford | New Jersey | 08848-1264 | United States | brewpub | |
| Deschutes Brewery | 901 SW Simpson Ave | Bend | Oregon | 97702-3118 | United States | regional | |
| Deschutes Brewery & Public House | 1044 NW Bond St | Bend | Oregon | 97703-2002 | United States | brewpub | |
| Deschutes Brewery & Public House | 210 NW 11th Ave | Portland | Oregon | 97209-2929 | United States | brewpub | |
| Desert Barn Brewing Co. | 11352 Hesperia Rd Ste B | Hesperia | California | 92345-2165 | United States | brewpub | |
| Desert Eagle Brewing Company | 150 W Main St | Mesa | Arizona | 85201-7310 | United States | micro | |
| Desert Edge Brewery | 551 E 600 S | Salt Lake City | Utah | 84102-2717 | United States | brewpub | |
| Desert Monks Brewing Co. | | Gilbert | Arizona | 85296-3480 | United States | planning | |
| Desert Valley Brewing Co. | 2809 Broadbent Pkwy NE, Suite D C/O The Craftroom | Albuquerque | New Mexico | 87107-1613 | United States | micro | |
| Deslogetown Brewery | 1669 Pine Ridge Trail | Park Hills | Missouri | 63601 | United States | brewpub | |
| Desperate Times Brewing Co | 1201 Carlisle Springs Rd | Carlisle | Pennsylvania | 17013-1554 | United States | brewpub | |
| DeSteeg Brewing Co/Blind Faith Brewing | 4342 Tennyson St | Denver | Colorado | 80212-2308 | United States | micro | |
| DESTIHL - Champaign | 301 N Neil St | Champaign | Illinois | 61820-3163 | United States | brewpub | |
| DESTIHL - Normal | 318 S Towanda Ave | Normal | Illinois | 61761-2212 | United States | brewpub | |
| DESTIHL Brewery | 1200 Greenbriar Dr | Normal | Illinois | 61761-6459 | United States | micro | |
| Destin Brewery | 505 Mountain Dr Ste N | Destin | Florida | 32541-7334 | United States | micro | |
| Destination Brewing Company | 2708 Lawrence Drive | Austin | Texas | 78734 | United States | contract | |
| Destination Unknown Beer Company | 1 S Chicago Ave Unit C | Bay Shore | New York | 11706-7000 | United States | micro | |
| Detroit Beer Co | 1529 Broadway St Ste 100 | Detroit | Michigan | 48226-2141 | United States | brewpub | |
| Deviant Wolfe Brewing | 121 W 1st St | Sanford | Florida | 32771-1201 | United States | micro | |
| Deviate Brewing Co | 4004 W 96th St | Indianapolis | Indiana | 46268-2909 | United States | micro | |
| Device Brewing Company | 8166 14th Ave | Sacramento | California | 95826-4722 | United States | micro | |